Transgender & PMDD

Transgender individuals with PMDD can be left without the necessary support needed. Just as cisgender women with PMDD can experience, the use of synthetic hormones and/or gonadotropin-releasing hormone agonist (GnRH agonistor GnRH–A) can be a trigger to more severe symptoms of depression, anxiety, rage, and suicidal ideation.

According to published guidelines from the Center of Excellence for Transgender Health, there is no clear evidence that testosterone therapy is directly associated with the onset of or worsening of mental health conditions, including PMDD. In fact it has been found that transgender men experience improvements in social functioning and reduced anxiety and depression once testosterone therapy is begun.

It is not well understood if transgender women are able to develop PMDD, although many do report PMS like symptoms when using hormone therapy. "Chemically induced PMDD" is quite plausible and further research is needed.

It is important to not attribute all symptoms of depression, anxiety, rage, or suicidial ideation to HRT, testosterone therapy, or beingtransgender. Tracking symptoms with a symptom tracker for two or more menstrual cycles can indicate PMDD or premenstrual exacerbation of an underlying disorder (PME). Fortunately, many trans individuals do report a lessening of symptoms from transition related healthcare including HRT and gender confirming surgery.


Suicide attempts among trans men are slightly higher than trans women at 46 percent to 42 percent respectively. The overall rate of transgender suicide is 41 percent, which vastly exceeds the 4.6 percent of the overall U.S. population who report a lifetime suicide attempt. For anyone living with PMDD, it is imperative to provide and seek support and crisis intervention regardless of gender identity.  

If you are in crisis please call the Trans Lifeline at US: (877) 565-8860 Canada: (877) 330-6366


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Further Reading

Updated  1/31/18

1.) 2017. Williamsinstitute.Law.Ucla.Edu. Accessed April 6 2017.
2.) "Guidelines For The Primary And Gender-Affirming Care Of Transgender And Gender-Nonconforming People: Overview Of Masculinizing Hormone Therapy". 2017. Transhealth.Ucsf.Edu. Accessed April 6 2017.
3.) "Basic Issues In Transgender Mental Health". 2009. Transgender Mental Health. Accessed April 6 2017.
4.) "What These Men Want You To Know About Their Periods". 2017. Mic.Com. Accessed April 6 2017.